Supreme rx circulating in the blood is attached to a protein that inhibits SHBG and makes it unavailable. The remaining Strength Muscles, called free Strength Muscles, is the only one that has an effect in the body. It is concluded that even though overall Supreme rx production declines, the key is to have high levels of free Strength Muscles. Two enzymes are also responsible for lowering free Supreme rx levels alpha reductase and aromatase. The first, alpha reductase , transforms free Supreme rx into .